Endocrine System Worksheets

Learn Six Major Endocrine Glands and their Hormones

The endocrine system worksheets provide lesson plans from the MatchCard Science Human Anatomy for grades 5 - 8. Identify six major glands and their most important hormones.

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endocrine worksheet

Human Anatomy Unit Study

MatchCard Science Endocrine System Worksheets

Objective: Identify where hormones are synthesized and their effect on the body.

MatchCard: Download below.

MatchCard Information Pieces describe the function and location of synthesis of six hormones. Ideas for projects are listed on the instructor's page and below.

Here's the Endocrine System MatchCard

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This is MatchCard #13 of the Human Anatomy Unit Study. Directions for using MatchCards are below.

The 1st page is the students' worksheet. The student will match the hormone, the gland, and the function of the hormone to the diagram of the endocrine system.

The 2nd page is the Instructor's Guide with the correct answers.

The 3rd page has the Information Pieces. Student's cut them apart and place them in the correct place on their copy of the Matchcard (first page.)

For more information on how to use the Matchcards, see the MatchCard Science Instructor's Guide.

What is a hormone?

The endocrine system is one of the most complicated systems of human anatomy to understand. It involves the production and secretion of hormones.

So what is a hormone? It is a substance produced in a gland in one part of the body that travels through the blood stream to another part of the body.

In some cases, it may affect every cell in the body. Insulin and thyroid hormone are examples of hormones that affect every cell. Others, such as progresterone, have a primary effect on a particular organ.

For this lesson, we are focusing on six endocrine glands and a major hormone of that gland. The number of hormones that are actually in the body are in the hundreds, and for every hormone there are multiple effects. This is a simple introduction to the concept of the endocrine system and its widespread impact on the body.

A Frightening Introduction

Describe this scenario:

You are walking all alone late at night. It's hard to see because it is so dark and it feels spooky. All of a sudden, something jumps out of a bush and grabs you.

Describe your reactions. Discuss fear. Discuss the physical effects of fear: involuntary scream, running, wide eyes, hair stands on end, heart races, breathing harder

Let students describe their own scenarios of fear and their reactions.

In the scenario above, imagine the person who jumped out was just a friend. Now you are laughing and no longer afraid. However, it takes a little while to calm down. You still feel jittery and shakey and your heart continues to beat fast.


The hormone adrenaline was released into your blood system from the adrenal glands on the kidneys. Adrenaline is released in response to fear, stress or anger.

Even though you are no longer scared, the adrenaline is still in your body and causing physical symptoms.

Discuss the fight or flight syndrome: adrenaline helps us fight enemies or flee for safety. It is a valuable hormone produced by a small gland you might not have known existed in your body.

Six Major Hormones

Identify the 6 Hormones on the Endocrine System Worksheets

For each of the six hormones listed on the endocrine system worksheets the student will identify: This is only an introduction to the endocrine system for kids. A goal of this lesson is for students to recognize that hormones are created in certain glands and affect cells in distant parts of the body.

Pituitary Gland

Location: Gland in the brain
Major hormone: Growth Hormone
Function: Causes bones and muscles to grow
Effect of malfunction: Growth restriction

Thyroid Gland

Location: Neck - in front of the pharynx (or throat)
Major Hormone: Thyroxin
Function: Increases the rate of metabolism in the cells of the body.
Effect of malfunction: Weight gain or weight loss

Adrenal Gland

Location: Kidneys - below the back ribs
Major Hormone: Adrenaline
Function: Causes the heart rate and breathing to increase
Effect of malfunction: Prolonged stress causes high blood pressure


Location: below stomach in left upper quadrant of the abdomen
Major Hormone: Insulin
Function: Carries glucose into the cells from the blood stream
Malfunction: Diabetes


Location: Male scrotum
Major Hormone: Testosterone
Function: Causes masculine characteristics and the production of sperm
Malfunction: Infertility


Location: Female pelvis (low abdomen)
Major Hormone: Estrogen
Function: Causes female characteristics and helps regulate the menstrual cycle

Other Major Hormone: Progesterone
Function: Prepares the uterine lining for an embryo and causes ovulation
Malfunction: Infertility

Other Ideas for the Study of the Endocrine System for Kids

Memory Game

You can play a matching game like "Memory" with the hormones. Instead of two cards, there are three to a set.

Place them face down, and they have to match them.

Hormones and Disease

Hormone deficiences can cause significant disease. Let them choose one hormone and research more about it. In addition to the physical effects, note how it impacts the life of the person as well.

Hormone Poster

Choose one of the endocrine glands. List other hormones that it produces.

Make a poster of the human body showing the different effects of the hormones from that one gland.

Science Experiment: Sugar, sugar everywhere

This experiment would require you to have access to a home glucose monitoring system which is available to diabetics. This experiment should not be done by a diabetic or someone with a hormone deficiency.

Keep track of the calories you eat and your blood glucose one hour after a meal. Draw a chart. What does it show?

Compare a favorite food if you eat at home or eat it at a restaurant. What does that show?

Do some foods cause blood glucose to spike sooner? Can you predict which? Develop a hypothesis and create an experiment to show it.

MatchCard Science

How To Use MatchCards


MatchCards make science concepts and corresponding vocabulary interactive. As students move the information pieces on the MatchCards they review the material they have already learned.

Download the FREE MatchCard Science Instructor's Guide and see how MatchCards can make building their science knowledge base fun.

Human Anatomy Unit Study

Human Anatomy Unit Study Cover

From cells to systems, kids will learn learn fun things about how their body works. 12 different human anatomy systems are covered.

Download the entire Human Anatomy Unit Study

12 Science Unit Studies

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Chemistry is only one of twelve complete unit studies for kids in 3rd to 8th grade.

Comprehensive objectives, hands-on projects, suggested science fair experiments, and the fun game-like MatchCards keep them interested in learning science. See all twelve MatchCard Science Unit Studies.

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